Malignant Hyperthermia

Malignant Hyperthermia Overview

Malignant Hyperthermia (MH) is a rare, inherited musculoskeletal syndrome that presents as a hypermetabolic reaction triggered by exposure to volatile anesthetic gases (e.g., desflurane, enflurane, halothane, sevoflurane) or the depolarizing muscle relaxant, succinylcholine.

The signs of MH include muscle rigidity, rapid heart rate, high body temperature, muscle breakdown, and increased acid content.

CRNAs/nurse anesthesiologists, resident registered nurse anesthetists, other clinicians, and facility administrators are encouraged to review available resources and assess their knowledge, preparedness, and training to periodically affirm the team’s readiness for an MH crisis.

Anesthesia professionals may be the first to recognize the onset of an MH crisis, but a coordinated team response is vital in the effective treatment and management of MH.

The Malignant Hyperthermia Association of the United States (MHAUS) has developed numerous resources and guidance for clinicians and patients to promote optimum care and scientific understanding of MH and related disorders.

MHAUS offers an emergency hotline for MH crises: 800-644-9737.

MHAUS also hosts the North American Malignant Hyperthermia Registry.