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By Maj. Anthony Peverini, CRNA, MS, US, AN
Capt. Kristin Amegin, CRNA, MS, US, AN
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The purpose of this observational study was to examine gender differences in the dosage of propofol required to attain and maintain sedation during lower extremity surgery under subarachnoid block. Standardized premedication with midazolam and fentanyl and placement of the subarachnoid block were carried out in accordance with the standard of care. Propofol was titrated to achieve a target sedation level as indicated by a bispectral index (BIS) score of 60 to 80. Data analysis using analysis of covariance (ANCOVA) demonstrated a statistically significant difference in the dosage of propofol required to attain and maintain sedation between men and women (p=.002 and p< /EM> =.019). This study found that during regional anesthesia using propofol for sedation, women require more propofol than men. This was true for dosages used to attain and maintain sedation.
Authors
Maj. Anthony Peverini, CRNA, MS, US, AN, was a student in the United States Army Graduate Program in Anesthesia Nursing at the time of this study. The study was the subject of a “State of the Science” oral presentation at the 2003 AANA Annual Meeting in Boston. Peverini currently works at Eisenhower Army Medical Center in Augusta, Ga.
Capt. Kristin Amegin, CRNA, MS, US, AN, was a student in the United States Army Graduate Program in Anesthesia Nursing at the time of this study. The study was the subject of a “State of the Science” oral presentation at the 2003 AANA Annual Meeting in Boston.
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